Search results for "STABILITY MECHANISM"
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Interfacial water structure controls protein conformation.
2007
A phenomenological theory of salt-induced Hofmeister phenomena is presented, based on a relation between protein solubility in salt solutions and protein-water interfacial tension. As a generalization of previous treatments, it implies that both kosmotropic salting out and chaotropic salting in are manifested via salt-induced changes of the hydrophobic/hydrophilic properties of protein-water interfaces. The theory is applied to describe the salt-dependent free energy profiles of proteins as a function of their water-exposed surface area. On this basis, three classes of protein conformations have been distinguished, and their existence experimentally demonstrated using the examples of bacter…
THE NEW ARCHITECTURE OF THE EUROPEAN ECONOMIC GOVERNANCE AND ITS CONSTITUTIONAL IMPLICATIONS AT THE EU AND NATIONAL LEVEL
La tesi analizza la nuova architettura costituzionale della governance economica europea come ridefinita dalle più recenti riforme europee predisposte al fine di contrastare la crisi economico-finanziaria dell’area euro e il suo impatto sull’assetto costituzionale dell’Unione europea e degli Stati Membri. La tesi, articolata in quattro capitoli e redatta interamente in lingua inglese, ripercorre le tappe salienti dell’evoluzione dell’Unione Economica e Monetaria, analizza le principali disposizioni della “costituzione economica” dell’Unione europea e contiene un’esposizione, in chiave critica, delle principali misure adottate dall’Unione europea per contrastare la crisi economica della zona…